It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. [10][11], Chlortalidone is considered a first-line medication for treatment high blood pressure. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. chlorthalidone is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. 2. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. Eventually, cardiac output returns to normal, and plasma and extracellular fluid volume return to slightly less than normal, but a reduction in peripheral vascular resistance is maintained, thus resulting in an overall lower blood pressure. Drug class (es): thiazide diuretics. High Blood Pressure. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. ... a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks. Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). Chlortalidone is used to treat high blood pressure (hypertension), and is also used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. Drug Name : Chlorthalidone. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets [5][12] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity. Grim on brand name for chlorthalidone: Normal BP in a 29yo is 750 mg. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. a sulfonamide diuretic, C14H11ClN2O4S, used in the management of hypertension. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. US Brand Name. High blood pressure adds to the workload of the heart and arteries. CHLORTHALIDONE Pronunciation: (klor thal' i done) Trade Name(s): Hythalton, hygroton, bigroton Why it is prescribed: Chlorthalidone, a water pill, is used to treat high blood pressure and fluid retention caused by various conditions.It causes the kidney to eliminate unneeded water and salt into the urine. Chlorthalidone manufacturer,Chlorthalidone 15mg,clonidine hcl 0.1mg,Chlorthalidone 100mg,Chlorthalidone 12.5mg Largest Generic Manufacturer,Formula,producing With chemical method according to the present invention Suppliers List,Molecular Structure,Weight,IUPAC,Synonyms for Chlorthalidone High Blood Pressure. [19] Chlortalidone is superior to angiotensin converting enzyme Inhibitors or angiotensin II receptor blockers for inducing regression of enlargement of the left ventricle, which is the main pumping chamber of the heart. The 25 mg tablets are light yellow, round, flat faced beveled edged unscored tablets debossed with "Z25" on one side of the tablet and plain on other side. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. [7][8] While it may be used in pregnancy it is a less preferred option. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to … Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. [48] Chlortalidone is freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol; it is also soluble in warm ethanol.[49]. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlorthalidone systemic is used in the treatment of: Edema. Chlorthalidone is an oral antihypertensive/diuretic. noun a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks • Syn: ↑Hygroton, ↑Thalidone • Hypernyms: ↑diuretic drug, ↑diuretic,… There is evidence that chlortalidone is superior to hydrochlorothiazide for reducing the mass of the left ventricle of the heart in persons with enlargement of the left ventricle of the heart. By blocking sodium ion resorption in the distal convoluted tubule, chlortalidone induces an increase in excretion of sodium ion in urine (natriuresis). It is taken by mouth. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Chlorthalidone is a "water pill " (diuretic). [1], Common side effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Stones in the urinary system can form in the kidneys and can sometimes travel down towards the bladder to give rise to acute colics. Atenolol/chlorthalidone is a combination of atenolol and chlorthalidone (Hygroton) used for the treatment of high blood pressure.Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system.Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. Chlorthalidone only comes as a tablet you take by mouth. 100 Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. Documented hypersensitivity to chlorthalidone or sulfonamides. Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … [9] It is available as a generic medication. Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. It also helps to relax the blood vessels so that blood can flow more easily. Due to its long half-life, chlortalidone may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose. Thalitone has a different formulation and is more potent. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. [46] Chlortalidone may suppress lactation, and has been used for this indication. Meaning of chlorthalidone. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. This can result in a low blood concentration of potassium and chloride as well as a mild metabolic alkalosis; however, the diuretic effect of chlortalidone is not affected by the acid-base balance of the person being treated. Chlorthalidone is a long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for … [42] Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. Drug information provided by: IBM Micromedex. you'll often start with a thiazide diuretic, such as: * chlorthalidone (hygroton) * chlorothiazide (diuril) * hydrochlorothiazide or hctz (esidrix, hydrodiuril, microzide) * indapamide (lozol) * Thalitone; Descriptions. Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. It is marketed in tablet form under the brand name Edarbi as the prodrug azilsartan medoxomil. Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. [20], Chlortalidone may improve edema (swelling) by increasing urinary salt and water excretion, lowering intravascular hydrostatic pressure and thereby lowering transcapillary pressure (see Starling Equation). [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase. Disclaimer - All information and content on this site are for information and educational purposes only. Effects generally begin within three hours and last for up to three days. This medication is used to treat high blood pressure (hypertension). chlorothiazide systemic. Anuria. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. [1] It is taken by mouth. [1][2] In high blood pressure it is a preferred initial treatment. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. Description and Brand Names. [22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. Chlorothiazide systemic is used in the treatment of: Edema. What is chlortalidone? Clorpres; Descriptions. [27] Chlortalidone is more effective than hydrochlorothiazide for lowering urine calcium levels and is therefore probably more effective. Generic Name: . In high blood pressure it is a preferred initial treatment. Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda. [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. Contraindications. It is 2-chloro-5(1-hydroxy- 3-oxo-1- isoindolinyl) benzenesulfonamide with the following structural formula: More Info about Chlorthalidone. This site complies with the HONcode standard for trustworthy health information: verify here. [51], O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2, InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21). 1-36. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. Definition of chlorthalidone in the Definitions.net dictionary. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. 1.3 Appearance, Color Chlorthalidone is a white to yellowish-white crystalline powder. [1] Some recommend chlortalidone over hydrochlorothiazide. In Analytical Profiles of Drug Substances, vol. chlorthalidone systemic. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Cautions. [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … Description and Brand Names. 14, pp. Singer, Jeff M., Michael J. O'Hare, Carl R. Rehm, and John E. Zarembo. [15] Chlortalidone, like other thiazides, appears effective in people with kidney disease. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Chlortalidone is a diuretic, which means it helps your body get rid of extra salt (sodium) and water.It works by increasing the amount of urine (pee) you make. There is uncertainty about the mechanism of the blood pressure-lowering effect that occurs during chronic exposure to chlortalidone. Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). [1] It is specifically a thiazide-like diuretic. [2] In 2017, it was the 173rd most commonly prescribed medication in the United States, with more than three million prescriptions. Chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg wi MedChem Express HY-15833: Membrane Tranporter/Ion Channel MedChem Express HY-15833 The most common adverse reaction in adults is diarrhea. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. apical ROMK/Na channels coupled with basolateral Na+/K ATPases). Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) [26] In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. Giving chlortalidone while simultaneously restricting dietary sodium intake causes mild hypovolemia (low intravascular volume), which induces isotonic reabsorption of solute from the proximal renal tubule, reducing solute delivery in the renal collecting tubule and renal medullary collecting duct. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. [47], Chlortalidone is in the sulfamoylbenzamide class. It is also used to prevent calcium-based kidney stones. [16], Chlortalidone and other thiazide diuretics are effective for lowering high blood pressure in persons with chronic kidney disease, although the risk of adverse effects is higher in these persons. [5] How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. [1] It is also used to prevent calcium-based kidney stones. Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. Diuretics such as chlortalidone also reduce the urine concentration of concomitantly-taken performance-enhancing drugs or of their metabolites, thus making it more difficult to detect these drugs using urine testing. Highlights for chlorthalidone. "Chlorthalidone." The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP It increases the amount of urine you make, especially when you first start the medication. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. 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